Blossom is the latest 90's show that COULD be coming back.
Star, Mayim Bialik, is currently on The Big Bang Theory (and has a PHD in neuroscience), but that doesn't mean she wouldn't be open to taking on the role of Blossom again.
According to Joey Lawrence, the two still talk frequently, and she's definitely open to doing some type of reunion or reboot of the show.